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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCNX All Species: 7.88
Human Site: S559 Identified Species: 14.44
UniProt: Q96RV3 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96RV3 NP_055797.2 2341 258676 S559 R T A S A H K S G R R R T G K
Chimpanzee Pan troglodytes XP_510039 2300 254005 A553 S G T K P H S A I F C H D E D
Rhesus Macaque Macaca mulatta XP_001084081 2342 258864 S560 R T A S A H K S G R R R T G K
Dog Lupus familis XP_537501 2332 257280 F563 G K K R A S S F D S S R H R D
Cat Felis silvestris
Mouse Mus musculus Q9QYC1 2344 258128 P562 R T T S A H K P G R R R T G K
Rat Rattus norvegicus NP_001163818 2343 257924 P561 R T T S A H K P G R R R T G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423893 2312 255194 E556 S A V F C H D E D S S D Q S D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923995 2285 252748 T557 C A S S L H S T H Q L S T D S
Tiger Blowfish Takifugu rubipres Q98UF7 1703 191329
Fruit Fly Dros. melanogaster P18490 3433 367590 S828 L H H H K A A S V E G A G P S
Honey Bee Apis mellifera XP_624687 2092 236172 V389 R R N E D G G V D N D S A N S
Nematode Worm Caenorhab. elegans NP_492790 1634 183268
Sea Urchin Strong. purpuratus XP_001195494 2799 311472 S607 H R L R S H S S S S S V S S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 98.7 94.4 N.A. 90.9 91.1 N.A. N.A. 84.9 N.A. 66.7 54.4 29.4 38.7 27.7 35.5
Protein Similarity: 100 98.1 99.4 96.4 N.A. 95.5 95.3 N.A. N.A. 90.8 N.A. 77.7 63 42.9 55.5 41.8 49.2
P-Site Identity: 100 6.6 100 13.3 N.A. 86.6 86.6 N.A. N.A. 6.6 N.A. 20 0 6.6 6.6 0 13.3
P-Site Similarity: 100 13.3 100 13.3 N.A. 86.6 86.6 N.A. N.A. 6.6 N.A. 40 0 6.6 6.6 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 16 0 39 8 8 8 0 0 0 8 8 0 0 % A
% Cys: 8 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 8 0 24 0 8 8 8 8 24 % D
% Glu: 0 0 0 8 0 0 0 8 0 8 0 0 0 8 0 % E
% Phe: 0 0 0 8 0 0 0 8 0 8 0 0 0 0 0 % F
% Gly: 8 8 0 0 0 8 8 0 31 0 8 0 8 31 8 % G
% His: 8 8 8 8 0 62 0 0 8 0 0 8 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 8 8 8 8 0 31 0 0 0 0 0 0 0 31 % K
% Leu: 8 0 8 0 8 0 0 0 0 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 8 0 0 0 8 0 % N
% Pro: 0 0 0 0 8 0 0 16 0 0 0 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % Q
% Arg: 39 16 0 16 0 0 0 0 0 31 31 39 0 8 0 % R
% Ser: 16 0 8 39 8 8 31 31 8 24 24 16 8 16 24 % S
% Thr: 0 31 24 0 0 0 0 8 0 0 0 0 39 0 0 % T
% Val: 0 0 8 0 0 0 0 8 8 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _